Genetic-Epigenetic Interactions in Asthma Revealed by a Genome-Wide Gene-Centric Search.

ABSTRACT:

Objectives

There is evidence to suggest that asthma pathogenesis is affected by both genetic and epigenetic variation independently, and there is some evidence to suggest that genetic-epigenetic interactions affect risk of asthma. However, little research has been done to identify such interactions on a genome-wide scale. The aim of this studies was to identify genes with genetic-epigenetic interactions associated with asthma.

Methods

Using asthma case-control data, we applied a novel nonparametric gene-centric approach to test for interactions between multiple SNPs and CpG sites simultaneously in the vicinities of 18,178 genes across the genome.

Results

Twelve genes, PF4, ATF3, TPRA1, HOPX, SCARNA18, STC1, OR10K1, UPK1B, LOC101928523, LHX6, CHMP4B, and LANCL1, exhibi

SUBMITTER: Kogan V 

PROVIDER: S-EPMC7365350 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature