The effect of susceptibility variants, identified in never-smoking female lung cancer cases, on male smokers.

ABSTRACT:

Background/aims

Genome wide and candidate gene association studies have identified polymorphisms associated with the risk of lung cancer in never-smokers. This study was conducted to evaluate the association between 11 polymorphisms identified in female never smokers and the lung cancer risk in male smokers.

Methods

This study included 714 lung cancer patients and 626 healthy controls. The polymorphisms were genotyped using SEQUENOM MassARRAY iPLEX assay or Taq-Man assay.

Results

Two polymorphisms were associated with the risk of lung cancer in male smokers, as in female never smokers. Male smokers carrying the rs4975616 variant allele had a significantly decreased risk of lung cancer (in a codominant model: odds ratio, 0.77; 95% confidence interval, 0.61 to 0.96; p =

SUBMITTER: Yoo SS 

PROVIDER: S-EPMC7373985 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature