Dataset Information

Longitudinal changes in symptom-based female and male LUTS clusters.

ABSTRACT:

Aims

Lower urinary tract symptoms (LUTS) are diverse in type and variable in severity. We examined symptom change within the Symptoms of the Lower Urinary Tract Dysfunction Research Network (LURN) Observational Cohort study identified clusters over time and tested associations with treatments received.

Methods

Patient-reported LUTS and treatment data were collected at multiple time points between baseline and 12 months from the LURN Observational Cohort study. LUTS severity scores were calculated to summarize changes in symptom reporting over time in previously identified LURN clusters. Repeated measures linear regression models tested adjusted associations between cluster membership and severity scores.

Results

Four-hundred seventeen men and 396 women were classified into improved, unchanged, and worsened symptoms between baseline and 12 months (men: 44.1%, 40.5%, and 15.3%; women: 55.8%, 33.1%, 11.1%, respectively). Improvement in LUTS severity scores varied by cluster (estimated adjusted mean change from baseline range: -.04 change in standard deviations of severity scores (ΔSD) to -.67 ΔSD). Prostate surgery was associated with improved severity scores (-.63 ΔSD) in men, while stress incontinence surgery was associated with improved severity scores (-.88 ΔSD) in women.

Conclusion

Symptom improvement varied by cluster indicating response to therapy differs amongst subtypes of patients with LUTS. The differential improvement of patients in clusters suggests mechanistic differences between clusters and may aid in selecting more targeted treatments in the future.

SUBMITTER: Amundsen CL

PROVIDER: S-EPMC7381999 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Publications

Longitudinal changes in symptom-based female and male LUTS clusters.

Amundsen Cindy L CL Helmuth Margaret E ME Smith Abigail R AR DeLancey John O L JOL Bradley Catherine S CS Flynn Kathryn E KE Kenton Kimberly S KS Henry Lai H H Cella David D Griffith James W JW Andreev Victor P VP Eric Jelovsek J J Liu Alice B AB Kirkali Ziya Z Yang Claire C CC

Neurourology and urodynamics 20191125 1

<h4>Aims</h4>Lower urinary tract symptoms (LUTS) are diverse in type and variable in severity. We examined symptom change within the Symptoms of the Lower Urinary Tract Dysfunction Research Network (LURN) Observational Cohort study identified clusters over time and tested associations with treatments received.<h4>Methods</h4>Patient-reported LUTS and treatment data were collected at multiple time points between baseline and 12 months from the LURN Observational Cohort study. LUTS severity scores ...[more]

PMID: 31765491

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Project description:Background: The interpretation of young athletes' performance during pubertal years is important to support coaches' decisions, as performance may be erroneously interpreted due to the misalignment between chronological age (CA), biological age (BA) and sport age (SA). Aim: Using a Bayesian multilevel approach, the variation in longitudinal changes in performance was examined considering the influence of CA, BA (age at menarche), SA, body size, and exposure to training among female basketball players. Method: The study had a mixed-longitudinal design. Thirty eight female basketball players (aged 13.38 ± 1.25 years at baseline) were measured three times per season. CA, BA and SA were obtained. Anthropometric and functional measures: countermovement jump, Line drill (LD), Yo-Yo (Yo-Yo IR1). Based on the sum of the z-scores, an index of overall performance was estimated. The effects of training on longitudinal changes in performance were modeled. Results: A decrease in the rate of improvements was apparent at about 14 years of age. When aligned for BA, the slowing of the rate of improvements is apparent about 2 years after menarche for LD. For countermovement jump longitudinal changes, when performance was aligned for BA improvements became linear. For Yo-Yo IR1 and performance index, both indicators showed a linear trend of improvement when aligned for CA and BA, separately. Older players showed higher rates of improvement for Yo-Yo IR1 and performance index from pre-season to end-season. When considering performance changes aligned for BA it was apparent an improvement of performance as players became biologically mature. Conclusions and Implications: The alignment of CA with BA and SA provides important information for coaches. Human growth follows a genetically determined pattern, despite variation in both tempo and timing. When the effects of maturation reach their end, all the girls went through the same process. Hence, there is no need to artificially manipulate youth competitions in order to accelerate gains that sooner or later reach their peak and tend to flat their improvement curve.

Dataset Information

Longitudinal changes in symptom-based female and male LUTS clusters.

Aims

Methods

Results

Conclusion

Publications

Longitudinal changes in symptom-based female and male LUTS clusters.

Similar Datasets

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