In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET.

ABSTRACT:

Introduction

Synaptic loss is a robust and consistent pathology in Alzheimer's disease (AD) and the major structural correlate of cognitive impairment. Positron emission tomography (PET) imaging of synaptic vesicle glycoprotein 2A (SV2A) has emerged as a promising biomarker of synaptic density.

Methods

We measured SV2A binding in 34 participants with early AD and 19 cognitively normal (CN) participants using [¹¹ C]UCB-J PET and a cerebellar reference region for calculation of the distribution volume ratio.

Results

We observed widespread reductions of SV2A binding in medial temporal and neocortical brain regions in early AD compared to CN participants. These reductions were largely maintained after correction for volume loss and were more extensive than decr

SUBMITTER: Mecca AP 

PROVIDER: S-EPMC7383876 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature