Dataset Information

Associations of rest-activity patterns with amyloid burden, medial temporal lobe atrophy, and cognitive impairment.

ABSTRACT:

Background

We sought to investigate the possible associations of rest-activity patterns with cortical amyloid burden, medial temporal lobe (MTL) neurodegeneration, and cognitive function in patients in the early stage of cognitive impairment.

Methods

Rest-activity patterns were assessed in 100 participants (70 with mild cognitive impairment and 30 with mild dementia) using wrist actigraphy. All participants underwent ¹⁸F-flutemetamol positron emission tomography (PET) imaging to quantify cortical amyloid burden, structural brain magnetic resonance imaging (MRI) to quantify MTL grey matter volume, neuropsychological testing, and clinical diagnosis. We used multiple linear regression models adjusted for covariates, including demographics, diabetes, hypertension, depressive symptom, psychotropic medication, sleep medication, weekend effect, and apolipoprotein-ε allele status.

Findings

After adjusting for possible confounders, we found that the midline estimation of statistic of rhythm (MESOR) associated positively with frontal/executive function (estimate = 1.17, standard error [SE] = 0.37, p = 0.002). The least active 5-h (L5) onset time associated positively with MTL grey matter volume and memory function (estimate = 1.24, SE = 0.33, p = 0.001, and estimate = 3.77, SE = 1.22, p = 0.003, respectively), particularly in amyloid-negative participants. Additional path analysis revealed that MTL grey matter volume partially mediated the association between L5 onset time and memory function in amyloid-negative participants.

Interpretation

Decreased MESOR and advanced L5 onset time may be useful as early signs of cognitive decline or MTL neurodegeneration. Furthermore, amyloid pathology may act as a moderator of the relationships between rest-activity patterns, neurodegeneration, and cognitive function.

Funding

Korea Centres for Disease Control and Prevention (#4845-303); National Research Foundation of Korea (2019M3C7A1031905, 2019R1A5A2026045).

SUBMITTER: Roh HW

PROVIDER: S-EPMC7394758 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Publications

Associations of rest-activity patterns with amyloid burden, medial temporal lobe atrophy, and cognitive impairment.

Roh Hyun Woong HW Choi Jung-Gu JG Kim Na-Rae NR Choe Yeong Sim YS Choi Jin Wook JW Cho Sun-Mi SM Seo Sang Won SW Park Bumhee B Hong Chang Hyung CH Yoon Dukyong D Son Sang Joon SJ Kim Eun Young EY

EBioMedicine 20200728

<h4>Background</h4>We sought to investigate the possible associations of rest-activity patterns with cortical amyloid burden, medial temporal lobe (MTL) neurodegeneration, and cognitive function in patients in the early stage of cognitive impairment.<h4>Methods</h4>Rest-activity patterns were assessed in 100 participants (70 with mild cognitive impairment and 30 with mild dementia) using wrist actigraphy. All participants underwent <sup>18</sup>F-flutemetamol positron emission tomography (PET) i ...[more]

PMID: 32736306

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Dataset Information

Associations of rest-activity patterns with amyloid burden, medial temporal lobe atrophy, and cognitive impairment.

Background

Methods

Findings

Interpretation

Funding

Publications

Associations of rest-activity patterns with amyloid burden, medial temporal lobe atrophy, and cognitive impairment.

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