Differences in molecular epidemiology of lung cancer among ethnicities (Asian vs. Caucasian).

ABSTRACT:

Background

Differences in carcinogenesis and therapeutic efficacy according to ethnicity have been reported for lung cancer, and understanding differences in genetic mutation profiles among ethnicities is important for interpreting the results of clinical trials, preventing carcinogenesis, and individualizing treatment. However, no studies have focused on differences in mutation profiles among different ethnicities using large-scale genomic analysis data with detailed information on smoking history, the main cause of lung cancer.

Methods

To clarify the differences in genetic mutation profiles between Caucasian and Japanese subjects, we compared data from The Cancer Genome Atlas, which mainly included Caucasians, with results from the Japan Molecular Epidemiology for lung can

SUBMITTER: Izumi M 

PROVIDER: S-EPMC7399397 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature