Urinary Excretion of N¹-Methylnicotinamide and N¹-Methyl-2-Pyridone-5-Carboxamide and Mortality in Kidney Transplant Recipients.

ABSTRACT: It is unclear whether niacin nutritional status is a target for improvement of long-term outcome after renal transplantation. The 24-h urinary excretion of N¹-methylnicotinamide (N¹-MN), as a biomarker of niacin status, has previously been shown to be negatively associated with premature mortality in kidney transplant recipients (KTR). However, recent evidence implies higher enzymatic conversion of N¹-MN to N¹-methyl-2-pyridone-5-carboxamide (2Py) in KTR, therefore the need exists for interpretation of both N¹-MN and 2Py excretion for niacin status assessment. We assessed niacin status by means of the 24-h urinary excretion of the sum of N¹-MN and 2Py (N¹-MN + 2Py),

SUBMITTER: Deen CPJ 

PROVIDER: S-EPMC7400946 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature