PM_2.5 impairs macrophage functions to exacerbate pneumococcus-induced pulmonary pathogenesis.

ABSTRACT:

Background

Pneumococcus is one of the most common human airway pathogens that causes life-threatening infections. Ambient fine particulate matter (PM) with aerodynamic diameter ≤ 2.5 μm (PM_2.5) is known to significantly contribute to respiratory diseases. PM_2.5-induced airway inflammation may decrease innate immune defenses against bacterial infection. However, there is currently limited information available regarding the effect of PM_2.5 exposure on molecular interactions between pneumococcus and macrophages.

Results

PM_2.5 exposure hampered macrophage functions, including phagocytosis and proinflammatory cytokine production, in response to pneumococcal infection. In a PM_2.5-exposed pneumococcus-infected mouse model, PM<

SUBMITTER: Chen YW 

PROVIDER: S-EPMC7409448 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature