Whole genome analysis reveals aneuploidies in early pregnancy loss in the horse.
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ABSTRACT:
SUBMITTER: Shilton CA
PROVIDER: S-EPMC7415156 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Whole genome analysis reveals aneuploidies in early pregnancy loss in the horse.
Shilton Charlotte A CA Kahler Anne A Davis Brian W BW Crabtree James R JR Crowhurst James J McGladdery Andrew J AJ Wathes D Claire DC Raudsepp Terje T de Mestre Amanda M AM
Scientific reports 20200807 1
The first 8 weeks of pregnancy is a critical time, with the majority of pregnancy losses occurring during this period. Abnormal chromosome number (aneuploidy) is a common finding in human miscarriage, yet is rarely reported in domestic animals. Equine early pregnancy loss (EPL) has no diagnosis in over 80% of cases. The aim of this study was to characterise aneuploidies associated with equine EPL. Genomic DNA from clinical cases of spontaneous miscarriage (EPLs; 14-65 days of gestation) and heal ...[more]
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