Six subphenotypes in septic shock: Latent class analysis of the PROWESS Shock study.

ABSTRACT:

Purpose

Septic shock is a highly heterogeneous condition which is part of the challenge in its diagnosis and treatment. In this study we aim to identify clinically relevant subphenotypes of septic shock using a novel statistic al approach.

Methods

Baseline patient data from a large global clinical trial of septic shock (n = 1696) was analysed using latent class analysis (LCA). This approach allowed investigators to identify subgroups in a heterogeneous population by estimating a categorical latent variable that detects relatively homogeneous subgroups within a complex phenomenon.

Results

LCA identified six different, clinically meaningful subphenotypes of septic shock each with a typical profile: (1) "Uncomplicated Septic Shock, (2) "Pneumonia with adult respiratory d

SUBMITTER: Gardlund B 

PROVIDER: S-EPMC7416734 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature