Drug-drug interactions with direct oral anticoagulants associated with adverse events in the real world: A systematic review.

ABSTRACT:

Background

Direct oral anticoagulants (DOACs) have emerged as safe and effective alternatives to Vitamin-K antagonists for treatment and prevention of arterial and venous thrombosis. Due to their novelty, pharmacokinetic DOAC drug-drug interactions (DDIs) that result in clinical adverse events have not been well-documented.

Objective

This study aims to systematically review reported pharmacokinetic DDIs resulting in clinical adverse events through documented observational evidence to better inform clinicians in clinical practice.

Methods

A comprehensive literature review of EMBASE, MEDLINE, and Ovid HealthStar was conducted through March 10th, 2020. Two independent reviewers screened and extracted data from eligible articles according to pre-established inclusion and

SUBMITTER: Li A 

PROVIDER: S-EPMC7417902 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature