Dose-Escalated Radiation Therapy for Pancreatic Cancer: A Simultaneous Integrated Boost Approach.

ABSTRACT:

Purpose

To provide a detailed description of practical approaches to dose escalation in pancreatic cancer.

Methods and materials

The current paper represents an international collaborative effort of radiation oncologists from the MR-linac consortium with expertise in pancreatic dose escalation.

Results

A 15-fraction hypofractionated intensity modulated radiation therapy (67.5 Gy in 15 fractions) and 5-fraction stereotactic body radiation therapy case (50 Gy in 5 fractions) are presented with information regarding patient selection, target volumes, organs at risk, dose constraints, and specific considerations regarding quality assurance. Additionally, we address barriers to dose escalation and briefly discuss future directions in dose escalation for pancreatic cancer,

SUBMITTER: Koay EJ 

PROVIDER: S-EPMC7423616 | biostudies-literature | 2020 Nov - Dec

REPOSITORIES: biostudies-literature