Explication of CB₁ receptor contributions to the hypothermic effects of Δ⁹-tetrahydrocannabinol (THC) when delivered by vapor inhalation or parenteral injection in rats.

ABSTRACT: The use of Δ⁹-tetrahydrocannabinol (THC) by inhalation using e-cigarette technology grows increasingly popular for medical and recreational purposes. This has led to development of e-cigarette based techniques to study the delivery of THC by inhalation in laboratory rodents. Inhaled THC reliably produces hypothermic and antinociceptive effects in rats, similar to effects of parenteral injection of THC. This study was conducted to determine the extent to which the hypothermic response depends on interactions with the CB₁ receptor, using pharmacological antagonist (SR141716, AM-251) approaches. Groups of rats were implanted with radiotelemetry devices capable of reporting activity and body temperature, which were assessed after THC inhalation or injection. SR141716 (4 m

SUBMITTER: Nguyen JD 

PROVIDER: S-EPMC7423642 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature