Perivascular Fibro-Adipogenic Progenitor Tracing during Post-Traumatic Osteoarthritis.

ABSTRACT: Perivascular mural cells surround capillaries and microvessels and have diverse regenerative or fibrotic functions after tissue injury. Subsynovial fibrosis is a well-known pathologic feature of osteoarthritis, yet transgenic animals for use in visualizing perivascular cell contribution to fibrosis during arthritic changes have not been developed. Here, inducible Pdgfra-CreER^T2 reporter mice were subjected to joint-destabilization surgery to induce arthritic changes, and cell lineage was traced over an 8-week period with a focus on the joint-associated fat pad. Results showed that, at baseline, inducible Pdgfra reporter activity highlighted adventitial and, to a lesser extent, pericytic cells within the infrapatellar fat pad. Joint-destabilization surgery was associated with mar

SUBMITTER: Sono T 

PROVIDER: S-EPMC7456743 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature