Endogenous estradiol and inflammation biomarkers: potential interacting mechanisms of obesity-related disease.

ABSTRACT:

Purpose

Disentangling the effects of endogenous estrogens and inflammation on obesity-related diseases requires a clearer understanding of how the two biological mechanisms relate to each other.

Methods

We studied 155 healthy postmenopausal women not taking menopausal hormone therapy enrolled in the Prostate Lung Colorectal and Ovarian (PLCO) screening cancer trial. From a baseline blood draw, we measured endogenous estradiol and 69 inflammation biomarkers: cytokines, chemokines, adipokines, angiogenic factors, growth factors, acute phase proteins, and soluble receptors. We evaluated the estradiol-inflammation relationship by assessing associations across different models (linear, ordinal logistic, and binary logistic) using a variety of estradiol classifications. We additio

SUBMITTER: Eldridge RC 

PROVIDER: S-EPMC7472689 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature