Significant Association between Microrna Gene Polymorphisms and Type 2 Diabetes Mellitus Susceptibility in Asian Population: A Meta-Analysis.

ABSTRACT:

Background

The gene polymorphisms in microRNA might relate to susceptibility of type 2 diabetes mellitus (T2DM). However, the results of existing studies were inconsistent and obscure. To investigate the precise associations between microRNA gene polymorphisms and T2DM risk, the present meta-analysis was performed.

Methods

The literatures were searched from four electronic databases, PubMed, Embase, CNKI and Wan-fang. Subsequently, odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were both used to evaluate the associations between two single nucleotide polymorphisms (SNPs) (microRNA146a rs2910164 (G>C), microRNA124a rs531564 (C>G)) and risk of T2DM in Asian population.

Results

Totally, there were 4 studies included in our present analysis in the

SUBMITTER: Deng Z 

PROVIDER: S-EPMC7475618 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature