Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.
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ABSTRACT:
SUBMITTER: Chen MH
PROVIDER: S-EPMC7480402 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.
Chen Ming-Huei MH Raffield Laura M LM Mousas Abdou A Sakaue Saori S Huffman Jennifer E JE Moscati Arden A Trivedi Bhavi B Jiang Tao T Akbari Parsa P Vuckovic Dragana D Bao Erik L EL Zhong Xue X Manansala Regina R Laplante Véronique V Chen Minhui M Lo Ken Sin KS Qian Huijun H Lareau Caleb A CA Beaudoin Mélissa M Hunt Karen A KA Akiyama Masato M Bartz Traci M TM Ben-Shlomo Yoav Y Beswick Andrew A Bork-Jensen Jette J Bottinger Erwin P EP Brody Jennifer A JA van Rooij Frank J A FJA Chitrala Kumaraswamynaidu K Cho Kelly K Choquet Hélène H Correa Adolfo A Danesh John J Di Angelantonio Emanuele E Dimou Niki N Ding Jingzhong J Elliott Paul P Esko Tõnu T Evans Michele K MK Floyd James S JS Broer Linda L Grarup Niels N Guo Michael H MH Greinacher Andreas A Haessler Jeff J Hansen Torben T Howson Joanna M M JMM Huang Qin Qin QQ Huang Wei W Jorgenson Eric E Kacprowski Tim T Kähönen Mika M Kamatani Yoichiro Y Kanai Masahiro M Karthikeyan Savita S Koskeridis Fotis F Lange Leslie A LA Lehtimäki Terho T Lerch Markus M MM Linneberg Allan A Liu Yongmei Y Lyytikäinen Leo-Pekka LP Manichaikul Ani A Martin Hilary C HC Matsuda Koichi K Mohlke Karen L KL Mononen Nina N Murakami Yoshinori Y Nadkarni Girish N GN Nauck Matthias M Nikus Kjell K Ouwehand Willem H WH Pankratz Nathan N Pedersen Oluf O Preuss Michael M Psaty Bruce M BM Raitakari Olli T OT Roberts David J DJ Rich Stephen S SS Rodriguez Benjamin A T BAT Rosen Jonathan D JD Rotter Jerome I JI Schubert Petra P Spracklen Cassandra N CN Surendran Praveen P Tang Hua H Tardif Jean-Claude JC Trembath Richard C RC Ghanbari Mohsen M Völker Uwe U Völzke Henry H Watkins Nicholas A NA Zonderman Alan B AB Wilson Peter W F PWF Li Yun Y Butterworth Adam S AS Gauchat Jean-François JF Chiang Charleston W K CWK Li Bingshan B Loos Ruth J F RJF Astle William J WJ Evangelou Evangelos E van Heel David A DA Sankaran Vijay G VG Okada Yukinori Y Soranzo Nicole N Johnson Andrew D AD Reiner Alexander P AP Auer Paul L PL Lettre Guillaume G
Cell 20200901 5
Most loci identified by GWASs have been found in populations of European ancestry (EUR). In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including 184,535 non-EUR individuals, we identified 5,552 trait-variant associations at p < 5 × 10<sup>-9</sup>, including 71 novel associations not found in EUR populations. We also identified 28 additional novel variants in ancestry-specific, non-EUR meta-analyses, including an IL7 missense variant in South Asians associate ...[more]
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