Sustained Weight Loss and Risk of Breast Cancer in Women 50 Years and Older: A Pooled Analysis of Prospective Data.

ABSTRACT:

Background

Excess body weight is an established cause of postmenopausal breast cancer, but it is unknown if weight loss reduces risk.

Methods

Associations between weight change and risk of breast cancer were examined among women aged 50 years and older in the Pooling Project of Prospective Studies of Diet and Cancer. In 10 cohorts, weight assessed on three surveys was used to examine weight change patterns over approximately 10 years (interval 1 median = 5.2 years; interval 2 median = 4.0 years). Sustained weight loss was defined as no less than 2 kg lost in interval 1 that was not regained in interval 2. Among 180 885 women, 6930 invasive breast cancers were identified during follow-up.

Results

Compared with women with stable weight (±2 kg), women with sustained weig

SUBMITTER: Teras LR 

PROVIDER: S-EPMC7492760 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature