Analysis of Ugandan cervical carcinomas identifies human papillomavirus clade-specific epigenome and transcriptome landscapes.
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ABSTRACT:
SUBMITTER: Gagliardi A
PROVIDER: S-EPMC7498180 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Analysis of Ugandan cervical carcinomas identifies human papillomavirus clade-specific epigenome and transcriptome landscapes.
Gagliardi Alessia A Porter Vanessa L VL Zong Zusheng Z Bowlby Reanne R Titmuss Emma E Namirembe Constance C Griner Nicholas B NB Petrello Hilary H Bowen Jay J Chan Simon K SK Culibrk Luka L Darragh Teresa M TM Stoler Mark H MH Wright Thomas C TC Gesuwan Patee P Dyer Maureen A MA Ma Yussanne Y Mungall Karen L KL Jones Steven J M SJM Nakisige Carolyn C Novik Karen K Orem Jackson J Origa Martin M Gastier-Foster Julie M JM Yarchoan Robert R Casper Corey C Mills Gordon B GB Rader Janet S JS Ojesina Akinyemi I AI Gerhard Daniela S DS Mungall Andrew J AJ Marra Marco A MA
Nature genetics 20200803 8
Cervical cancer is the most common cancer affecting sub-Saharan African women and is prevalent among HIV-positive (HIV<sup>+</sup>) individuals. No comprehensive profiling of cancer genomes, transcriptomes or epigenomes has been performed in this population thus far. We characterized 118 tumors from Ugandan patients, of whom 72 were HIV<sup>+</sup>, and performed extended mutation analysis on an additional 89 tumors. We detected human papillomavirus (HPV)-clade-specific differences in tumor DNA ...[more]
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