Unknown

Dataset Information

0

Location, Location, Location: Compartmentalization of NAD+ Synthesis and Functions in Mammalian Cells.


ABSTRACT: The numerous biological roles of NAD+ are organized and coordinated via its compartmentalization within cells. The spatial and temporal partitioning of this intermediary metabolite is intrinsic to understanding the impact of NAD+ on cellular signaling and metabolism. We review evidence supporting the compartmentalization of steady-state NAD+ levels in cells, as well as how the modulation of NAD+ synthesis dynamically regulates signaling by controlling subcellular NAD+ concentrations. We further discuss potential benefits to the cell of compartmentalizing NAD+, and methods for measuring subcellular NAD+ levels.

SUBMITTER: Cambronne XA 

PROVIDER: S-EPMC7502477 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Location, Location, Location: Compartmentalization of NAD<sup>+</sup> Synthesis and Functions in Mammalian Cells.

Cambronne Xiaolu A XA   Kraus W Lee WL  

Trends in biochemical sciences 20200625 10


The numerous biological roles of NAD<sup>+</sup> are organized and coordinated via its compartmentalization within cells. The spatial and temporal partitioning of this intermediary metabolite is intrinsic to understanding the impact of NAD<sup>+</sup> on cellular signaling and metabolism. We review evidence supporting the compartmentalization of steady-state NAD<sup>+</sup> levels in cells, as well as how the modulation of NAD<sup>+</sup> synthesis dynamically regulates signaling by controlling  ...[more]

Similar Datasets

| S-EPMC7718333 | biostudies-literature
| S-EPMC2919072 | biostudies-literature
| S-EPMC6657305 | biostudies-literature
| S-EPMC10087438 | biostudies-literature
| S-EPMC3496714 | biostudies-literature
| S-EPMC6448761 | biostudies-literature
| S-EPMC10080998 | biostudies-literature
| S-EPMC6516145 | biostudies-literature
| S-EPMC5834711 | biostudies-literature
| S-EPMC11226967 | biostudies-literature