Location, Location, Location: Compartmentalization of NAD⁺ Synthesis and Functions in Mammalian Cells.

ABSTRACT: The numerous biological roles of NAD⁺ are organized and coordinated via its compartmentalization within cells. The spatial and temporal partitioning of this intermediary metabolite is intrinsic to understanding the impact of NAD⁺ on cellular signaling and metabolism. We review evidence supporting the compartmentalization of steady-state NAD⁺ levels in cells, as well as how the modulation of NAD⁺ synthesis dynamically regulates signaling by controlling subcellular NAD⁺ concentrations. We further discuss potential benefits to the cell of compartmentalizing NAD⁺, and methods for measuring subcellular NAD⁺ levels.

SUBMITTER: Cambronne XA 

PROVIDER: S-EPMC7502477 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature