Ontology highlight
ABSTRACT:
SUBMITTER: Cambronne XA
PROVIDER: S-EPMC7502477 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Cambronne Xiaolu A XA Kraus W Lee WL
Trends in biochemical sciences 20200625 10
The numerous biological roles of NAD<sup>+</sup> are organized and coordinated via its compartmentalization within cells. The spatial and temporal partitioning of this intermediary metabolite is intrinsic to understanding the impact of NAD<sup>+</sup> on cellular signaling and metabolism. We review evidence supporting the compartmentalization of steady-state NAD<sup>+</sup> levels in cells, as well as how the modulation of NAD<sup>+</sup> synthesis dynamically regulates signaling by controlling ...[more]