ECMO for severe ARDS: systematic review and individual patient data meta-analysis.

ABSTRACT:

Purpose

To assess the effect of venovenous extracorporeal membrane oxygenation (ECMO) compared to conventional management in patients with severe acute respiratory distress syndrome (ARDS).

Methods

We conducted a systematic review and individual patient data meta-analysis of randomised controlled trials (RCTs) performed after Jan 1, 2000 comparing ECMO to conventional management in patients with severe ARDS. The primary outcome was 90-day mortality. Primary analysis was by intent-to-treat.

Results

We identified two RCTs (CESAR and EOLIA) and combined data from 429 patients. On day 90, 77 of the 214 (36%) ECMO-group and 103 of the 215 (48%) control group patients had died (relative risk (RR), 0.75, 95% confidence interval (CI) 0.6-0.94; P = 0.013; I² = 0%).

SUBMITTER: Combes A 

PROVIDER: S-EPMC7537368 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature