Longitudinal [¹⁸F]FDG-PET/CT analysis of the glucose metabolism in ApoE-deficient mice.

ABSTRACT:

Background

Strong line of evidence suggests that the increased risk to develop AD may at least be partly mediated by cholesterol metabolism. A key regulator of cholesterol transport is the Apolipoprotein E4 (ApoE4), which plays a fundamental role in neuronal maintenance and repair. Impaired function of ApoE4 may contribute to altered cerebral metabolism leading to higher susceptibility to neurodegeneration.

Methods

To determine a possible link between ApoE function and alterations in AD in the brain of Apolipoprotein E-deficient mice (ApoE-/-) in a longitudinal manner metabolic and neurochemical parameters were analyzed. Cortical metabolism was measured by 2-deoxy-2-[¹⁸F]fluoroglucose ([¹⁸F]FDG)-PET/CT and proton magnetic resonance spectroscopy (^1<

SUBMITTER: Kuhla A 

PROVIDER: S-EPMC7541807 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature