Dataset Information

Longitudinal [¹⁸F]FDG-PET/CT analysis of the glucose metabolism in ApoE-deficient mice.

ABSTRACT:

Background

Strong line of evidence suggests that the increased risk to develop AD may at least be partly mediated by cholesterol metabolism. A key regulator of cholesterol transport is the Apolipoprotein E4 (ApoE4), which plays a fundamental role in neuronal maintenance and repair. Impaired function of ApoE4 may contribute to altered cerebral metabolism leading to higher susceptibility to neurodegeneration.

Methods

To determine a possible link between ApoE function and alterations in AD in the brain of Apolipoprotein E-deficient mice (ApoE-/-) in a longitudinal manner metabolic and neurochemical parameters were analyzed. Cortical metabolism was measured by 2-deoxy-2-[¹⁸F]fluoroglucose ([¹⁸F]FDG)-PET/CT and proton magnetic resonance spectroscopy (¹H-MRS) served to record neurochemical status.

Results

By using [¹⁸F]FDG-PET/CT, we showed that brain metabolism declined significantly stronger with age in ApoE-/- versus wild type (wt) mice. This difference was particularly evident at the age of 41 weeks in almost each analyzed brain region. In contrast, the ¹H-MRS-measured N-acetylaspartate to creatine ratio, a marker of neuronal viability, did not decline with age and did not differ between ApoE-/- and wt mice.

Conclusion

In summary, this longitudinal in vivo study shows for the first time that ApoE-/- mice depict cerebral hypometabolism without neurochemical alterations.

SUBMITTER: Kuhla A

PROVIDER: S-EPMC7541807 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Publications

Longitudinal [<sup>18</sup>F]FDG-PET/CT analysis of the glucose metabolism in ApoE-deficient mice.

Kuhla Angela A Meuth Lou L Stenzel Jan J Lindner Tobias T Lappe Chris C Kurth Jens J Krause Bernd J BJ Teipel Stefan S Glass Änne Ä Kundt Guenther G Vollmar Brigitte B

EJNMMI research 20201007 1

<h4>Background</h4>Strong line of evidence suggests that the increased risk to develop AD may at least be partly mediated by cholesterol metabolism. A key regulator of cholesterol transport is the Apolipoprotein E4 (ApoE4), which plays a fundamental role in neuronal maintenance and repair. Impaired function of ApoE4 may contribute to altered cerebral metabolism leading to higher susceptibility to neurodegeneration.<h4>Methods</h4>To determine a possible link between ApoE function and alterations ...[more]

PMID: 33029684

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Dataset Information

Longitudinal [¹⁸F]FDG-PET/CT analysis of the glucose metabolism in ApoE-deficient mice.

Background

Methods

Results

Conclusion

Publications

Longitudinal [<sup>18</sup>F]FDG-PET/CT analysis of the glucose metabolism in ApoE-deficient mice.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Longitudinal [18F]FDG-PET/CT analysis of the glucose metabolism in ApoE-deficient mice.

Background

Methods

Results

Conclusion

Publications

Longitudinal [<sup>18</sup>F]FDG-PET/CT analysis of the glucose metabolism in ApoE-deficient mice.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Longitudinal [¹⁸F]FDG-PET/CT analysis of the glucose metabolism in ApoE-deficient mice.