Maternal Serum Lipid Trajectories and Association with Pregnancy Loss and Length of Gestation.

ABSTRACT:

Objective

We characterized lipid trajectories and investigated lipids and rate of pregnancy lipid change with the risk of pregnancy loss or preterm delivery <37 weeks.

Study design

In a secondary analysis of 337 women with one to two prior losses assigned to placebo in a randomized controlled trial at four centers (2007-2012), cholesterol, low- and high-density lipoprotein cholesterol (HDL-C), and triglycerides were measured up to 6 months prepregnancy (time 0) and pregnancy up to 7 visits. Trajectories were created using linear mixed models. Multivariable logistic regression with adjustment for maternal characteristics and cholesterol was performed.

Results

Lipids decreased from prepregnancy to 4 to 5 weeks, followed by an increase, and were biphasic or triphasic dep

SUBMITTER: Grantz KL 

PROVIDER: S-EPMC7558414 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature