Apolipoprotein E ε4 allele effects on longitudinal cognitive trajectories are sex and age dependent.

ABSTRACT:

Introduction

Questions remain about whether apolipoprotein E (APOE)-ε4 effects on cognitive decline are similar in men and women and how APOE-ε4 and age interact to influence decline in different cognitive domains.

Methods

In sex-stratified analyses, baseline age-dependent associations between APOE-ε4 status and longitudinal cognitive trajectories were examined in cognitively normal Caucasian older adults (631 men, 561 women, baseline age range: 50-93, 6733 assessments).

Results

In men, older baseline age was associated with greater effects of APOE-ε4 on longitudinal decline in memory and executive function, detectible from baseline age of 64 and 68, respectively. In women, older baseline age was associated with greater APOE-ε4 effects on longitudinal decline in atten

SUBMITTER: Williams OA 

PROVIDER: S-EPMC7561018 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature