Compulsivity is linked to reduced adolescent development of goal-directed control and frontostriatal functional connectivity.

ABSTRACT: A characteristic of adaptive behavior is its goal-directed nature. An ability to act in a goal-directed manner is progressively refined during development, but this refinement can be impacted by the emergence of psychiatric disorders. Disorders of compulsivity have been framed computationally as a deficit in model-based control, and have been linked also to abnormal frontostriatal connectivity. However, the developmental trajectory of model-based control, including an interplay between its maturation and an emergence of compulsivity, has not been characterized. Availing of a large sample of healthy adolescents (n = 569) aged 14 to 24 y, we show behaviorally that over the course of adolescence there is a within-person increase in model-based control, and this is more pronounced in yo

SUBMITTER: Vaghi MM 

PROVIDER: S-EPMC7568330 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature