Endothelin-1 contributes to the development of virus-induced demyelinating disease.

ABSTRACT:

Background

Experimental autoimmune encephalitis (EAE) and virally induced demyelinating disease are two major experimental model systems used to study human multiple sclerosis. Although endothelin-1 level elevation was previously observed in the CNS of mice with EAE and viral demyelinating disease, the potential role of endothelin-1 in the development of these demyelinating diseases is unknown.

Methods and results

In this study, the involvement of endothelin-1 in the development and progression of demyelinating diseases was investigated using these two experimental models. Administration of endothelin-1 significantly promoted the progression of both experimental diseases accompanied with elevated inflammatory T cell responses. In contrast, administration of specific endothel

SUBMITTER: Jin YH 

PROVIDER: S-EPMC7568825 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature