Incremental prognostic value and underlying biological pathways of radiomics patterns in medulloblastoma.

ABSTRACT:

Background

To develop a radiomics signature for predicting overall survival (OS)/progression-free survival (PFS) in patients with medulloblastoma (MB), and to investigate the incremental prognostic value and biological pathways of the radiomics patterns.

Methods

A radiomics signature was constructed based on magnetic resonance imaging (MRI) from a training cohort (n = 83), and evaluated on a testing cohort (n = 83). Key pathways associated with the signature were identified by RNA-seq (GSE151519). Prognostic value of pathway genes was assessed in a public GSE85218 cohort.

Findings

The radiomics-clinicomolecular signature predicted OS (C-index 0.762) and PFS (C-index 0.697) better than either the radiomics signature (C-index: OS: 0.649; PFS: 0.593) or the clinicomolecu

SUBMITTER: Yan J 

PROVIDER: S-EPMC7581926 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature