Effect of polymorphisms on TGFB1 on allergic asthma and helminth infection in an African admixed population.

ABSTRACT:

Background

Allergic asthma is a complex disorder that results from a combination of genetic and environmental factors. Studies suggest that helminth infections can activate a regulatory network characterized by the production of regulatory cytokines, such as interleukin 10 and transforming growth factor β1 (TGF-β1) and subsequently protect against immune-mediated diseases, such as asthma. On the other hand, TGF-β1 is increased in the lungs of individuals with asthma and may modulate airway inflammation. The role of TGF- β 1 single-nucleotide polymorphisms (SNPs) in allergic disease remains inconclusive.

Objective

To evaluate the effects of genetic variations in the TGF-β1 on allergy and helminths infections in children.

Methods

We tested for association among 4 TGF-β1

SUBMITTER: Costa RD 

PROVIDER: S-EPMC7612854 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature