Phase-based masking for quantitative susceptibility mapping of the human brain at 9.4T.

ABSTRACT:

Purpose

To develop improved tissue masks for QSM.

Methods

Masks including voxels at the brain surface were automatically generated from the magnitude alone (MM) or combined with test functions from the first (PG) or second (PB) derivative of the sign of the wrapped phase. Phase images at 3T and 9.4T were simulated at different TEs and used to generate a mask, P_Itoh , with between-voxel phase differences less than π. MM, PG, and PB were compared with P_Itoh . QSM were generated from 3D multi-echo gradient-echo data acquired at 9.4T (21 subjects aged: 20-56y), and from the QSM2016 challenge 3T data using different masks, unwrapping, background removal, and dipole inversion algorithms. QSM contrast was quantified using age-based iron concentrations.

Resu

SUBMITTER: Hagberg GE 

PROVIDER: S-EPMC7613679 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature