Assessment of a Polygenic Risk Score in Screening for Prostate Cancer.

ABSTRACT:

Background

The incidence of prostate cancer is increasing. Screening with an assay of prostate-specific antigen (PSA) has a high rate for false positive results. Genomewide association studies have identified common germline variants in persons with prostate cancer, which can be used to calculate a polygenic risk score associated with risk of prostate cancer.

Methods

We recruited persons 55 to 69 years of age from primary care centers in the United Kingdom. Using germline DNA extracted from saliva, we derived polygenic risk scores from 130 variants known to be associated with an increased risk of prostate cancer. Participants with a polygenic risk score in the 90th percentile or higher were invited to undergo prostate cancer screening with multiparametric magnetic resonance

SUBMITTER: McHugh JK 

PROVIDER: S-EPMC7617604 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature