A local difference in blood-brain barrier permeability in the caudate putamen and thalamus of a rat brain induced by focused ultrasound.

ABSTRACT: A blood-brain barrier (BBB) opening induced by focused ultrasound (FUS) has been widely studied as an effective way of treating brain diseases. We investigate the effect of ultrasound's incidence angle at caudate putamen (Cp) and thalamus (Th) of the rat brain by inducing the same power of focused ultrasound that corresponds to the acoustic pressure of 0.65 MPa in free field. The BBB permeability (K_trans) was quantitatively evaluated with dynamic contrast-enhanced magnetic resonance imaging. The group averaged (n = 11) maximum K_trans at Cp (0.021 ± 0.012 min^-1) was 1.39 times smaller than the K_trans of Th (0.029 ± 0.01 min^-1) with p = 0.00343. The group averaged (n = 6) ultrasound's incidence angles measured using the computed tomograp

SUBMITTER: Huh H 

PROVIDER: S-EPMC7648079 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature