In situ sprayed NIR-responsive, analgesic black phosphorus-based gel for diabetic ulcer treatment.

ABSTRACT: The treatment of diabetic ulcer (DU) remains a major clinical challenge due to the complex wound-healing milieu that features chronic wounds, impaired angiogenesis, persistent pain, bacterial infection, and exacerbated inflammation. A strategy that effectively targets all these issues has proven elusive. Herein, we use a smart black phosphorus (BP)-based gel with the characteristics of rapid formation and near-infrared light (NIR) responsiveness to address these problems. The in situ sprayed BP-based gel could act as 1) a temporary, biomimetic "skin" to temporarily shield the tissue from the external environment and accelerate chronic wound healing by promoting the proliferation of endothelial cells, vascularization, and angiogenesis and 2) a drug "reservoir" to store therapeutic BP and pa

SUBMITTER: Ouyang J 

PROVIDER: S-EPMC7682336 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature