Global regulatory features of alternative splicing across tissues and within the nervous system of C. elegans.

ABSTRACT: Alternative splicing plays a major role in shaping tissue-specific transcriptomes. Among the broad tissue types present in metazoans, the central nervous system contains some of the highest levels of alternative splicing. Although many documented examples of splicing differences between broad tissue types exist, there remains much to be understood about the splicing factors and the cis sequence elements controlling tissue and neuron subtype-specific splicing patterns. By using translating ribosome affinity purification coupled with deep-sequencing (TRAP-seq) in Caenorhabditis elegans, we have obtained high coverage profiles of ribosome-associated mRNA for three broad tissue classes (nervous system, muscle, and intestine) and two neuronal subtypes (dopaminergic and serotonergi

SUBMITTER: Koterniak B 

PROVIDER: S-EPMC7706725 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature