Ontology highlight
ABSTRACT:
SUBMITTER: Bell LCK
PROVIDER: S-EPMC7721347 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Bell Lucy C K LCK Meydan Cem C Kim Jacob J Foox Jonathan J Butler Daniel D Mason Christopher E CE Shapira Sagi D SD Noursadeghi Mahdad M Pollara Gabriele G
iScience 20201207 1
Dysregulated IL-1β and IL-6 responses have been implicated in the pathogenesis of severe Coronavirus Disease 2019 (COVID-19). Innovative approaches for evaluating the biological activity of these cytokines <i>in vivo</i> are urgently needed to complement clinical trials of therapeutic targeting of IL-1β and IL-6 in COVID-19. We show that the expression of IL-1β or IL-6 inducible transcriptional signatures (modules) reflects the bioactivity of these cytokines in immunopathology modelled by juveni ...[more]