Essential Role of Neutrophils in the Protective Immune Response Induced by a Live Attenuated Leishmania Vaccine.

ABSTRACT: No licensed vaccine exists against visceral leishmaniasis (VL), a disease caused by the Leishmania donovani parasite. We have previously reported both macrophages and dendritic cells play important role in the protection induced by a live attenuated centrin gene-deleted L. donovani (LdCen^-/- ) parasite vaccine. The role of neutrophils in orchestrating the initial innate response to pathogens is widely recognized. To investigate the early interaction of LdCen^-/- with neutrophils, we immunized mice intradermally in the ear pinna with LdCen^-/- Compared with LdWT infection, LdCen^-/- parasites induced higher recruitment of neutrophils to the ear dermis and ear draining lymph nodes (dLN) as early as 6-18

SUBMITTER: Bhattacharya P 

PROVIDER: S-EPMC7725841 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature