House dust microbiota in relation to adult asthma and atopy in a US farming population.

ABSTRACT:

Background

Bacterial exposure from house dust has been associated with asthma and atopy in children but whether these relationships are present in adults remains unclear.

Objective

We sought to examine associations of house dust microbiota with adult asthma, atopy, and hay fever.

Methods

Vacuumed bedroom dust samples from the homes of 879 participants (average age, 62 years) in the Agricultural Lung Health Study, a case-control study of asthma nested within a farming cohort, were subjected to 16S rRNA amplicon sequencing to characterize bacterial communities. We defined current asthma and hay fever using questionnaires and current atopy by blood specific IgE level > 0.70 IU/mL to 1 or more of 10 common allergens. We used linear regression to examine whether overall wi

SUBMITTER: Lee MK 

PROVIDER: S-EPMC7770060 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature