Decrease in membrane fluidity and traction force induced by silica-coated magnetic nanoparticles.

ABSTRACT:

Background

Nanoparticles are being increasingly used in biomedical applications owing to their unique physical and chemical properties and small size. However, their biophysical assessment and evaluation of side-effects remain challenging. We addressed this issue by investigating the effects of silica-coated magnetic nanoparticles containing rhodamine B isothiocyanate [MNPs@SiO₂(RITC)] on biophysical aspects, such as membrane fluidity and traction force of human embryonic kidney 293 (HEK293) cells. We further extended our understanding on the biophysical effects of nanoparticles on cells using a combination of metabolic profiling and transcriptomic network analysis.

Results

Overdose (1.0 μg/µL) treatment with MNPs@SiO₂(RITC) induced lipid peroxidation a

SUBMITTER: Shin TH 

PROVIDER: S-EPMC7802323 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature