Polygenic risk scores for Alzheimer's disease are related to dementia risk in APOE ɛ4 negatives.

ABSTRACT:

Introduction

Studies examining the effect of polygenic risk scores (PRS) for Alzheimer's disease (AD) and apolipoprotein E (APOE) genotype on incident dementia in very old individuals are lacking.

Methods

A population-based sample of 2052 individuals ages 70 to 111, from Sweden, was followed in relation to dementia. AD-PRSs including 39, 57, 1333, and 13,942 single nucleotide polymorphisms (SNPs) were used.

Results

AD-PRSs (including 39 or 57 SNPs) were associated with dementia (57-SNPs AD-PRS: hazard ratio 1.09, confidence interval 1.01-1.19, P = .03), particularly in APOE ɛ4 non-carriers (57-SNPs AD-PRS: 1.15, 1.05-1.27, P = 4 × 10^-3, 39-SNPs AD-PRS: 1.22, 1.10-1.35, P = 2 × 10^-4). No association was found wit

SUBMITTER: Najar J 

PROVIDER: S-EPMC7821873 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature