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Prevalence of pharmacogenomic variants in 100 pharmacogenes among Southeast Asian populations under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm).


ABSTRACT: Pharmacogenomics can enhance the outcome of treatment by adopting pharmacogenomic testing to maximize drug efficacy and lower the risk of serious adverse events. Next-generation sequencing (NGS) is a cost-effective technology for genotyping several pharmacogenomic loci at once, thereby increasing publicly available data. A panel of 100 pharmacogenes among Southeast Asian (SEA) populations was resequenced using the NGS platform under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm). Here, we present the frequencies of pharmacogenomic variants and the comparison of these pharmacogenomic variants among different SEA populations and other populations used as controls. We investigated the different types of pharmacogenomic variants, especially those that may have a functional impact. Our results provide substantial genetic variations at 100 pharmacogenomic loci among SEA populations that may contribute to interpopulation variability in drug response phenotypes. Correspondingly, this study provides basic information for further pharmacogenomic investigations in SEA populations.

SUBMITTER: Runcharoen C 

PROVIDER: S-EPMC7862625 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Prevalence of pharmacogenomic variants in 100 pharmacogenes among Southeast Asian populations under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm).

Runcharoen Chakkaphan C   Fukunaga Koya K   Sensorn Insee I   Iemwimangsa Nareenart N   Klumsathian Sommon S   Tong Hang H   Vo Nam Sy NS   Le Ly L   Hlaing Tin Maung TM   Thant Myo M   Zain Shamsul Mohd SM   Mohamed Zahurin Z   Pung Yuh-Fen YF   Capule Francis F   Nevado Jose J   Silao Catherine Lynn CL   Al-Mahayri Zeina N ZN   Ali Bassam R BR   Yuliwulandari Rika R   Prayuni Kinasih K   Zahroh Hilyatuz H   Noor Dzul Azri Mohamed DAM   Xangsayarath Phonepadith P   Xayavong Dalouny D   Kounnavong Sengchanh S   Sayasone Somphou S   Kordou Zoe Z   Liopetas Ioannis I   Tsikrika Athina A   Tsermpini Evangelia-Eirini EE   Koromina Maria M   Mitropoulou Christina C   Patrinos George P GP   Kesornsit Aumpika A   Charoenyingwattana Angkana A   Wattanapokayakit Sukanya S   Mahasirimongkol Surakameth S   Mushiroda Taisei T   Chantratita Wasun W  

Human genome variation 20210204 1


Pharmacogenomics can enhance the outcome of treatment by adopting pharmacogenomic testing to maximize drug efficacy and lower the risk of serious adverse events. Next-generation sequencing (NGS) is a cost-effective technology for genotyping several pharmacogenomic loci at once, thereby increasing publicly available data. A panel of 100 pharmacogenes among Southeast Asian (SEA) populations was resequenced using the NGS platform under the collaboration of the Southeast Asian Pharmacogenomics Resea  ...[more]

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