Progression of Geographic Atrophy with Subsequent Exudative Neovascular Disease in Age-Related Macular Degeneration: AREDS2 Report 24.

ABSTRACT:

Purpose

To examine whether the rate of geographic atrophy (GA) enlargement is influenced by subsequent exudative neovascular age-related macular degeneration (nAMD) and hence, to explore indirectly whether nonexudative nAMD may slow GA enlargement.

Design

Post hoc analysis of a controlled clinical trial cohort.

Participants

Age-Related Eye Disease Study 2 participants 50 to 85 years of age.

Methods

Baseline and annual stereoscopic color fundus photographs were evaluated for (1) GA presence and area and (2) exudative nAMD presence. Two cohorts were constructed: eyes with GA at study baseline (prevalent cohort) and eyes in which GA developed during follow-up (incident cohort). Mixed-model regression of the square root of GA area was performed according to the pre

SUBMITTER: Hwang CK 

PROVIDER: S-EPMC7870515 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature