Risk of adverse coronavirus disease 2019 outcomes for people living with HIV.

ABSTRACT:

Objective

To assess whether people living with HIV (PLWH) are at increased risk of coronavirus disease 2019 (COVID-19) mortality or adverse outcomes, and whether antiretroviral therapy (ART) influences this risk.

Design

Rapid review with meta-analysis and narrative synthesis.

Methods

We searched databases including Embase, Medline, medRxiv and Google Scholar up to 26 August 2020 for studies describing COVID-19 outcomes in PLWH and conducted a meta-analysis of higher quality studies.

Results

We identified 1908 studies and included 19 in the review. In a meta-analysis of five studies, PLWH had a higher risk of COVID-19 mortality [hazard ratio 1.95, 95% confidence interval (CI): 1.62-2.34] compared with people without HIV. Risk of death remained elevated for PLWH

SUBMITTER: Mellor MM 

PROVIDER: S-EPMC7924978 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature