Dose-response relationship between genetically proxied average blood glucose levels and incident coronary heart disease in individuals without diabetes mellitus.

ABSTRACT:

Aims/hypothesis

Our aim was to investigate the relationship between average blood glucose levels and incident CHD in individuals without diabetes mellitus.

Methods

To investigate average blood glucose levels, we studied HbA_1c as predicted by 40 variants previously shown to be associated with both type 2 diabetes and HbA_1c. Linear and non-linear Mendelian randomisation analyses were performed to investigate associations with incident CHD risk in 324,830 European ancestry individuals from the UK Biobank without diabetes mellitus.

Results

Every one mmol/mol increase in genetically proxied HbA_1c was associated with an 11% higher CHD risk (HR 1.11, 95% CI 1.05, 1.18). The dose-response curve increased at all levels of HbA_1c, and

SUBMITTER: Burgess S 

PROVIDER: S-EPMC7940279 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature