Growth and development of islet autoimmunity and type 1 diabetes in children genetically at risk.

ABSTRACT:

Aims/hypothesis

We aimed to evaluate the relationship between childhood growth measures and risk of developing islet autoimmunity (IA) and type 1 diabetes in children with an affected first-degree relative and increased HLA-conferred risk. We hypothesised that being overweight or obese during childhood is associated with a greater risk of IA and type 1 diabetes.

Methods

Participants in a randomised infant feeding trial (N = 2149) were measured at 12 month intervals for weight and length/height and followed for IA (at least one positive out of insulin autoantibodies, islet antigen-2 autoantibody, GAD autoantibody and zinc transporter 8 autoantibody) and development of type 1 diabetes from birth to 10-14 years. In this secondary analysis, Cox proportional hazard regression mod

SUBMITTER: Nucci AM 

PROVIDER: S-EPMC7940594 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature