Population Attributable Fractions of Modifiable Risk Factors for Nonsyndromic Orofacial Clefts: A Prospective Cohort Study From the Japan Environment and Children's Study.

ABSTRACT:

Background

Population impact of modifiable risk factors on orofacial clefts is still unknown. This study aimed to estimate population attributable fractions (PAFs) of modifiable risk factors for nonsyndromic cleft lip with or without cleft palate (CL±P) and cleft palate only (CP) in Japan.

Methods

We conducted a prospective cohort study using data from the Japan Environment and Children's Study, which recruited pregnant women from 2011 to 2014. We estimated the PAFs of maternal alcohol consumption, psychological distress, maternal active and passive smoking, abnormal body mass index (BMI) (<18.5 and ≥25 kg/m²), and non-use of a folic acid supplement during pregnancy for nonsyndromic CL±P and CP in babies.

Results

A total of 94,174 pairs of pregnant women an

SUBMITTER: Sato Y 

PROVIDER: S-EPMC7940975 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature