Macrophage immunomodulation through new polymers that recapitulate functional effects of itaconate as a power house of innate immunity.
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ABSTRACT:
SUBMITTER: Huyer LD
PROVIDER: S-EPMC7942808 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
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Macrophage immunomodulation through new polymers that recapitulate functional effects of itaconate as a power house of innate immunity.
Huyer L Davenport LD Mandla S S Wang Y Y Campbell S S Yee B B Euler C C Lai B F BF Bannerman D D Lin D S Y DSY Montgomery M M Nemr K K Bender T T Epelman S S Mahadevan R R Radisic M M
Advanced functional materials 20201113 6
Itaconate (ITA) is an emerging powerhouse of innate immunity with therapeutic potential that is limited in its ability to be administered in a soluble form. We developed a library of polyester materials that incorporate ITA into polymer backbones resulting in materials with inherent immunoregulatory behavior. Harnessing hydrolytic degradation release from polyester backbones, ITA polymers resulted in the mechanism specific immunoregulatory properties on macrophage polarization in vitro. In a fun ...[more]
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