Ontology highlight
ABSTRACT:
SUBMITTER: Enriquez-Hesles E
PROVIDER: S-EPMC7949035 | biostudies-literature | 2021 Jan-Jun
REPOSITORIES: biostudies-literature
Enriquez-Hesles Elisa E Smith Daniel L DL Maqani Nazif N Wierman Margaret B MB Sutcliffe Matthew D MD Fine Ryan D RD Kalita Agata A Santos Sean M SM Muehlbauer Michael J MJ Bain James R JR Janes Kevin A KA Hartman John L JL Hirschey Matthew D MD Smith Jeffrey S JS
The Journal of biological chemistry 20201202
Caloric restriction (CR) improves health span and life span of organisms ranging from yeast to mammals. Understanding the mechanisms involved will uncover future interventions for aging-associated diseases. In budding yeast, Saccharomyces cerevisiae, CR is commonly defined by reduced glucose in the growth medium, which extends both replicative and chronological life span (CLS). We found that conditioned media collected from stationary-phase CR cultures extended CLS when supplemented into nonrest ...[more]