Differential effects of bariatric surgery and caloric restriction on hepatic one-carbon and fatty acid metabolism.

ABSTRACT: Weight loss interventions, including dietary changes, pharmacotherapy, or bariatric surgery, prevent many of the adverse consequences of obesity, and may also confer intervention-specific benefits beyond those seen with decreased weight alone. We compared the molecular effects of different interventions on liver metabolism to understand the mechanisms underlying these benefits. Male rats on a high-fat, high-sucrose diet underwent sleeve gastrectomy (SG) or intermittent fasting with caloric restriction (IF-CR), achieving equivalent weight loss. The interventions were compared to ad-libitum (AL)-fed controls. Analysis of liver and blood metabolome and transcriptome revealed distinct and sometimes contrasting metabolic effects between the two interventions. SG primarily influenced one-

SUBMITTER: Haran A 

PROVIDER: S-EPMC10300224 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature