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IGFBP-1 in cancer: expression, molecular mechanisms, and potential clinical implications.

ABSTRACT: Insulin-like growth factor binding protein-1 (IGFBP-1) belongs to the insulin-like growth factor (IGF) system, which plays an indispensable role in normal growth and development, and in the pathophysiology of various tumors. IGFBP-1 has been shown to be associated with the risk of various tumors, and has a vital function in regulating tumor behaviors such as proliferation, migration, invasion and adhesion through different molecular mechanisms. The biological actions of IGFBP-1 in cancer are found to be related to its phosphorylation state, and the IGF-dependent and -independent mechanisms. In this review, we provided an overview of IGFBP-1 in normal physiology, and its aberrantly expression and the underlying molecular mechanisms in a range of common tumors, as well as discussed the potential clinical implications of IGFBP-1 as diagnostic or prognostic biomarkers in cancer.

SUBMITTER: Lin YW

PROVIDER: S-EPMC8014352 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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IGFBP-1 in cancer: expression, molecular mechanisms, and potential clinical implications.

Lin Yi-Wei YW Weng Xue-Fen XF Huang Bin-Liang BL Guo Hai-Peng HP Xu Yi-Wei YW Peng Yu-Hui YH

American journal of translational research 20210315 3

Insulin-like growth factor binding protein-1 (IGFBP-1) belongs to the insulin-like growth factor (IGF) system, which plays an indispensable role in normal growth and development, and in the pathophysiology of various tumors. IGFBP-1 has been shown to be associated with the risk of various tumors, and has a vital function in regulating tumor behaviors such as proliferation, migration, invasion and adhesion through different molecular mechanisms. The biological actions of IGFBP-1 in cancer are fou ...[more]

PMID: 33841624

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