A multivariate neuromonitoring approach to neuroplasticity-based computerized cognitive training in recent onset psychosis.

ABSTRACT: Two decades of studies suggest that computerized cognitive training (CCT) has an effect on cognitive improvement and the restoration of brain activity. Nevertheless, individual response to CCT remains heterogenous, and the predictive potential of neuroimaging in gauging response to CCT remains unknown. We employed multivariate pattern analysis (MVPA) on whole-brain resting-state functional connectivity (rsFC) to (neuro)monitor clinical outcome defined as psychosis-likeness change after 10-hours of CCT in recent onset psychosis (ROP) patients. Additionally, we investigated if sensory processing (SP) change during CCT is associated with individual psychosis-likeness change and cognitive gains after CCT. 26 ROP patients were divided into maintainers and improvers based on their SP change duri

SUBMITTER: Haas SS 

PROVIDER: S-EPMC8027389 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature