Comprehensive profiling of the gut microbiota in patients with chronic obstructive pulmonary disease of varying severity.

ABSTRACT: Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease that reduces lung and respiratory function, with a high mortality rate. Severe and acute deterioration of COPD can easily lead to respiratory failure, resulting in personal, social, and medical burden. Recent studies have shown a high correlation between the gut microbiota and lung inflammation. In this study, we investigated the relationship between gut microbiota and COPD severity. A total of 60 COPD patients with varying severity according to GOLD guidelines were enrolled in this study. DNA was extracted from patients' stool and 16S rRNA data analysis conducted using high-throughput sequencing followed by bioinformatics analysis. The richness of the gut microbiota was not associated with COPD severity. The gut

SUBMITTER: Chiu YC 

PROVIDER: S-EPMC8034725 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature